SARS-Cov-2: “IHU” The New Alarming Variant Discovered by French MDs and Raoult: Microbiologist Skeptical of Vaccines
by Fabio Giuseppe Carlo Carisio
«SARS-CoV-2 variants have become a major virological, epidemiological and clinical concern, particularly with regard to the risk of escape from vaccine-induced immunity. Here we describe the emergence of a new variant. For twelve SARS-CoV-positive patients living in the same geographical area of southeastern France, qPCR testing that screen for variant-associated mutations showed an atypical combination. The index case returned from a travel in Cameroon».
Thus begins the Abstract of a preprint research, still to be revised, published on December 29 in the specialist journal MedRxiv which refers to the British Medical Journal by some French scientists. The discovery of a new Covid-19 mutation only became public knowledge yesterday after the DailyMail first reported it.
«In France, where Omicron pushes the wave of Covid infections, a new variant of the Coronavirus has been identified that has 46 mutations and is defined as a ‘distant relative’ of the mutation that has been dominating the scene for about a month. So far 12 cases have been identified starting with patient zero, a traveler from Cameroon» writes Adnkronos, press agency in Italy.
The study was conducted by Philippe Colson, Jérémy Delerce, Emilie Burel, Jordan Dahan, Agnès Jouffret, Florence Fenollar, Nouara Yahi, Jacques Fantini, Bernard La Scola, Didier Raoult through the institutes where Aix-Marseille Université and IHU Méditerranée Infection operate, from which the new IHU variant took its name while waiting for the World Health Organization to evaluate its diffusion and eventually assign it an international name, probably in the case of π (pi), which comes after Omicron.
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Among the scientists stands out the name of Professor Raoult, director of the IHU Méditerranée Infection and professor of microbiology and medicine, specialist in infectious diseases, targeted by the scientific community for his studies on the effectiveness of Hydroxychlorichin which cost him a disciplinary procedure but they also became the subject of a French parliament investigation into alleged sabotage by an American pharmaceutical company.
Raoult himself, in October, had highlighted on Twitter a research that questioned the strategy of vaccines as the only weapon against Covid-19, especially for the resistance to experimental gene serums of the Delta variant, very widespread at the end of the summer. , and for fear of subsequent ones.
THE MUTATIONS AFTER RESISTANCE TO VACCINES
The discovery of this new Coronavirus strain therefore represents for the Marseille professor the confirmation of his fears about the rapid emergence and spread of new mutations of the virus, that the virologist Luc Montagnier, the vaccine expert Geert Vanden Bossche, the pharmacological chemist Loretta Bolgan and the biologist Franco Trinca, attribute the massive immunization campaign (for now only attempted, given the very poor results) to the vaccine-resistance mechanism.
«The genomes were obtained by next-generation sequencing with Oxford Nanopore Technologies on GridION instruments within ≈8 h. Their analysis revealed 46 mutations and 37 deletions resulting in 30 amino acid substitutions and 12 deletions. Fourteen amino acid substitutions, including N501Y and E484K, and 9 deletions are located in the spike protein»,
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«The WHO has not yet given it a name, we have called it IHU and it has been deposited on the Gisaid science sharing network with the name B.1.640.2» said Professor Philippe Colson, head of the unit that discovered less than a month ago, but «it hasn’t spread rapidly since then» he told the Daily Mail.
«The variant would present the E484K mutation, associated with greater resistance to vaccines, and the N501Y mutation – already seen in the Alpha variant – which according to experts could favor greater transmissibility. In some ways, according to the identikit, the new variant would appear as a ‘distant relative’ of Omicron» highlights Adnkronos.
«This genotype pattern led to create a new Pangolin lineage named B.1.640.2, which is a phylogenetic sister group to the old B.1.640 lineage renamed B.1.640.1. Both lineages differ by 25 nucleotide substitutions and 33 deletions. The mutation set and phylogenetic position of the genomes obtained here indicate based on our previous definition a new variant we named “IHU”. These data are another example of the unpredictability of the emergence of SARS-CoV-2 variants, and of their introduction in a given geographical area from abroad» noted the paper.
THE RESEARCH ON VACCINES SPREADED BY RAOULT
«The European Journal of Epidemiology, of which I am editor, is the most popular epidemiology journal in the world. Here, he points out the lack of correlation between the vaccination policy and the number of cases ». With this Tweet, Professor Didier Raoult credited a study published on September 30 in the specialized journal Springer by two young American scientists: S. V. Subramania, Harvard Center for Population and Development Studies, Cambridge, MA, USA Department of Social and Behavioral Sciences, Harvard T.H. Chan School of Public Health, Boston, MA, USA, and Akhil Kumar, Turner Fenton Secondary School, Brampton, ON, Canada.
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«Vaccines currently are the primary mitigation strategy to combat COVID-19 around the world. For instance, the narrative related to the ongoing surge of new cases in the United States (US) is argued to be driven by areas with low vaccination rates . A similar narrative also has been observed in countries, such as Germany and the United Kingdom . At the same time, Israel that was hailed for its swift and high rates of vaccination has also seen a substantial resurgence in COVID-19 cases . We investigate the relationship between the percentage of population fully vaccinated and new COVID-19 cases across 68 countries and across 2947 counties in the US».
This is what is reported in the abstract of the finished study among the controversies because some French scientists contested its brevity and speed, as it was carried out in just 7 days.
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«The sole reliance on vaccination as a primary strategy to mitigate COVID-19 and its adverse consequences needs to be re-examined, especially considering the Delta (B.1.617.2) variant and the likelihood of future variants. Other pharmacological and non-pharmacological interventions may need to be put in place alongside increasing vaccination rates. Such course correction, especially with regards to the policy narrative, becomes paramount with emerging scientific evidence on real world effectiveness of the vaccines».
These are the same doubts expressed by Professor Raoult in an interview with the French media Midi Libre: «The program I have read so far seemed to me to be science fiction. So far what I’ve seen is mostly advertising. I haven’t seen any scientific articles, I’m waiting to see some real data. For vaccines, including those widely used like influenza, we know that the target actually reacts quite badly because immunity is deteriorating, with age in particular.
«The strategy of our countries and of France was not the worst from this point of view, England made a vaccination program that was taken over by the WHO, the Americans did the same, of therapeutic evaluation without requiring that there was at least one diagnostic test. In Africa we don’t do it, nobody does it, to make a diagnosis they do a test» added Raoult.
«We do not include in therapeutic studies, for the folly of doing therapeutic studies, people whose diagnosis we do not know. If we had fun making this mandatory vaccine you would cause a revolution. You don’t have to do something that you don’t know if it’s dangerous, you don’t know if it works and you make it mandatory, so it’s really crazy».
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Raoult therefore defines “madness” as what has become ordinary practice in Italy despite the complaints of the affected categories. Among them there are also the policemen who, with the support of the COSAP union lawyer, requested the specialist medical prescription, which is essential in the opinion of the lawyer Renate Holzeisen according to the current European and Italian health regulations.
The Marseille professor then specifies that vaccination is the choice of each person, as if to seek treatment. «Then there is individual protection, the individual risk that we theoretically have the right to take, but in this country we no longer even have this right. When you are prevented from taking drugs (with reference to chloroquine, ed) that you want to take, it is still that you no longer have the right to decide what to do. But I am liberal from this point of view, if you decide to cure yourself or to stop yourself from taking this vaccine you do it which is different from the state policy that says you have to do it».
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«We live in a world that is crazy. The conditions that were taken to combat this disease are conditions from another century. These are not practical conditions, it is not a daily struggle. Already telling people, don’t cure yourself, stay home, it’s not even the Middle Ages, not even Hippocrates did it. He didn’t tell people to stay home until you die … It’s crazy. “The politicians believed from the beginning that there would be a magic wand. The experts of this magic wand believed that it would come from the pharmaceutical industry» is the bitter observation of Raoult that opens the door to the conclusions of the research published below. Ocean.
STRONGER NATURAL IMMUNITY THAN VACCINES
«For instance, in a report released from the Ministry of Health in Israel, the effectiveness of 2 doses of the BNT162b2 (Pfizer-BioNTech) vaccine against preventing COVID-19 infection was reported to be 39% , substantially lower than the trial efficacy of 96% . It is also emerging that immunity derived from the Pfizer-BioNTech vaccine may not be as strong as immunity acquired through recovery from the COVID-19 virus . A substantial decline in immunity from mRNA vaccines 6-months post immunization has also been reported . Even though vaccinations offers protection to individuals against severe hospitalization and death, the CDC reported an increase from 0.01 to 9% and 0 to 15.1% (between January to May 2021) in the rates of hospitalizations and deaths, respectively, amongst the fully vaccinated » add the North American researchers.
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«In summary, even as efforts should be made to encourage populations to get vaccinated it should be done so with humility and respect. Stigmatizing populations can do more harm than good. Importantly, other non-pharmacological prevention efforts (e.g., the importance of basic public health hygiene with regards to maintaining safe distance or handwashing, promoting better frequent and cheaper forms of testing) needs to be renewed in order to strike the balance of learning to live with COVID-19 in the same manner we continue to live a 100 years later with various seasonal alterations of the 1918 Influenza virus».
This is the self-evident conclusion of the scientists S. V. Subramania and Akhil Kumar.
Fabio Giuseppe Carlo Carisio
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