“Obelisks”, Unknown Viroids found in Human Gut: might have been Generated by Harmful mRNA Vaccines! US University discovered Anomalous Genomes, Proteins

“Obelisks”, Unknown Viroids found in Human Gut: might have been Generated by Harmful mRNA Vaccines! US University discovered Anomalous Genomes, Proteins

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by Fabio Giuseppe Carlo Carisio

VERSIONE IN ITALIANO

«As they collect and analyze massive amounts of genetic sequences from plants, animals, and microbes, biologists keep encountering surprises, including some that may challenge the very definition of life. The latest, reported this week in a preprint, is a new kind of viruslike entity that inhabits bacteria dwelling in the human mouth and gut».

«These “obelisks,” as they’re called by the Stanford University team that unearthed them, have genomes seemingly composed of loops of RNA and sequences belonging to them have been found around the world».

Official “science” speaks up to this point because this is how an article just published in SCIENCE Journal begins in relation to this sensational biochemical discovery.

Science Journal image of unknown Obelisks discovered in human intestinal metabiota

Now you will read my personal intuitions based on the association of four different scientific studies that refer to characteristics similar to those of these “viroids” vaguely similar to the hepatitis D virus because they require another virus to replicate.

The worrying issue is that such research refers to the behavior of the Spike protein of SARS-Cov-2 enhanced in the viral load in the laboratory with alteration of the furin enzyme cleavage site and with the insertion of plasmids of the HIV virus (that causes AIDS syndrome), as now recognized by every virologist on the planet worthy of the name.

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But above all they concern four studies and a scientific article conducted on the alterations created in RNA by messenger RNA COVID genetic sera.

The Anomalous Coincidences between Obelisks and mRNA Gene Sera against SARS-Cov-2

Starting from these premises, here is the logical speculation of a simple syllogism:

These unknown circular RNA rings capable of encoding a new superfamily of proteins (while viroids are normally unable to encode proteins) may have been generated by the interaction of vaccine mRNA in the human body.

To avoid appearing crazy to biochemistry experts (which I am not despite having now studied around 400 studies on SARS, Covid-19 and mRNA biotechnology) I will immediately expose the crucial points that led me to such a risky correlation which scientists, obviously, being the pre-print research, they don’t expose it so as not to see it immediately censored…

  • The authors of the research themselves make a small allusion to the mRNA of the COVID gene sera but, obviously, they are careful not to hypothesize a correlation
  • These new Obelisk genomic entities nestle in the human intestinal metabiota where the molecules of the SARS-Cov-2 virus are hidden, which have bacteriophage characteristics therefore similar to these “viroid-like”
  • They are composed of loops of RNA with fewer bases than true viruses but are able to encode new proteins unlike standard viroids.
  • The coding of new dangerous proteins is one of the disturbing consequences of the diabolical molecule N1-methylpseudouridine created in the laboratory in the mRNA biotechnology of Covid vaccines to deceive the dendritic cells of the blood called to suppress every organism foreign to human cells.
  • A very recent study by the French biomathematician Jean-Claude Perez has highlighted that N1-methylpseudouridine inserted into mRNA gene sera can generate dangerous proteins such as killer prions, responsible for lethal neurocerebral diseases such as human Mad Cow Disease (CJD), or the so-called “eating amoeba”. brain”.
  • N1-methylpseudouridine is obtained from the manipulation of the uridine nucleoside which is made up of the coupling of a ribose molecule and a uracil molecule. Uracil is one of the two pyrimidine nitrogenous bases that form the nucleotides of RNA nucleic acid.

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  • A study by the University of Cambridge confirmed that this modified nucleoside is responsible for the so-called ‘frame-shifting’, i.e. the “slips” along the mRNA sequence.
  • Frameshift errors occur when the cell’s protein-making machinery accidentally gets a base or two wrong in the mRNA sequence. Because mRNA bases are read in groups of three, a frameshift breaks the original sets of the sequence, affecting all sequences downstream of the error.
  • Therefore, it is of considerable importance that the new viroid-like Obelisks have a lower number of bases than those of viral genomes and are different from the anomalous Hepatitis D sub-virus which requires another virus to transmit.
  • Not only. In research from Stanford University it is hypothesized that they may be RNA plasmids which therefore could have a correlation with the dangerous plasmids/DNA fragments detected in the vials of the Comirnaty (Pfizer-Biotech) and Spikevax (Moderna) vaccines and considered oncogenic to the point of lead the Florida Surgeon General to call for a complete and immediate halt to all Covid vaccines
  • Finally, the same researchers detect an anomalous folding of the RNA sequences just like the one created in the laboratory in the codons of mRNA vaccines

Sure of having demonstrated to an expert not only the importance of the discovery of the viroid-like Obelisk and the mysterious Oblin protein generated by them, let’s look at those essential parts for the reader who is not even expert in biochemistry and the interconnections with the studies on SARS-Cov-2 and related vaccines.

Also because, as shown in Figure 3 of the Supplementary Material of the new Stanford study, these new genomic entities were more widespread in the Western countries most vaccinated against Covid…

In the meantime, we will send this article to biochemistry experts to get their opinion. We did not want to consult them immediately in order to take full credit for this sensational scientific intuition which, if confirmed, would be of global importance.

Is the Obelisk Viroid-Like transmitted by another virus?

Let’s start with one of the “many questions” posed by Stanford biologist (California, USA) Andrew Fire, his graduate student Ivan Zheludev and their colleagues in the study just published on BioRxiv entitled “Viroid-like colonists of human microbiomes”.

The cover of the Obelisk research

Here is the question together with all the other questions from scientists which could perhaps be answered in part if associated with Covid-19, the toxic Spike protein, and the N1-methylpseudouridine of vaccines capable of altering human DNA…

«Many questions arise about the Obelisks. Does their transmission involve a separate, more complex, infectious agent (like HDV)? Do they primarily spread via virus-like particles, or cytoplasmically like viroids?».

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  • «Are Obelisks plasmid-like in that they can co-exist, and in some cases, contribute to host adaptability and fitness?
  • Like viroids and HDV, do Obelisks replicate via rolling circle replication using a co-opted host RNA polymerase?
  • What roles do the apparently circular Obelisk genome topology and the evidently conserved Obelisk genomic secondary structure play in the Obelisk lifecycle?
  • Is Oblin-1 an RNA binding protein, and how does domain-A factor into its function? Does Oblin-2 act as a competitive inhibitor of host leucine zippers, as a multimerizing element, and/or can it interact with Oblin-1?
  • How do Obelisks that lack Oblin-2 complement its function(s)? What role do the Obelisk-specific self-cleaving ribozymes play, and how do they interact with the Oblin proteins?
  • How do Obelisks affect their host, and are they largely a deleterious or beneficial element to harbour? And what impact, if any, does harbouring an Obelisk have on ‘meta’-host physiology, is Obelisk positivity predictive of human health states?»

The Genomic Description of the Unknown Obelisks

Let’s now see what Zheludev et al, wrote in the Abstract of their Research in which, however, some essential passages are missing which we have identified with difficulty and will report later.

«Here, we describe the “Obelisks,” a previously unrecognised class of viroid-like elements that we first identified in human gut metatranscriptomic data. “Obelisks” share several properties: (i) apparently circular RNA 1kb genome assemblies, (ii) predicted rod-like secondary structures encompassing the entire genome, and (iii) open reading frames coding for a novel protein superfamily, which we call the “Oblins”».

How is it possible not to think about the anomalous proteins produced by the manipulation of uracil in RNA discovered by Professor Perez’s latest explosive study, carried out with the Montagnier Foundation in memory of his late scientist friend with whom he had already revealed the killer prion proteins of mRNA vaccines?

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«We find that Obelisks form their own distinct phylogenetic group with no detectable sequence or structural similarity to known biological agents. Further, Obelisks are prevalent in tested human microbiome metatranscriptomes with representatives detected in 7% of analysed stool metatranscriptomes (29/440) and in 50% of analysed oral metatranscriptomes (17/32)» we can still read it in research from Stanford University.

«Obelisk compositions appear to differ between the anatomic sites and are capable of persisting in individuals, with continued presence over >300 days observed in one case. Large scale searches identified 29,959 Obelisks (clustered at 90% nucleotide identity), with examples from all seven continents and in diverse ecological niches. From this search, a subset of Obelisks are identified to code for Obelisk-specific variants of the hammerhead type-III self-cleaving ribozyme».

«Lastly, we identified one case of a bacterial species (Streptococcus sanguinis) in which a subset of defined laboratory strains harboured a specific Obelisk RNA population. As such, Obelisks comprise a class of diverse RNAs that have colonised, and gone unnoticed in, human, and global microbiomes».

Bacteria of the Human Gut Metabiota where SARS-Cov-2 Bacteriophage nests

«Obelisks appear to be globally distributed (Figure 3c) and are a constituent member of the human oral and gut microbiomes, occurring in ~10 % of human donors in five assayed human metatranscriptomic studies» we read further in the Research Discussion Zheludev et al.

«A single clear Obelisk-host pairing (S. Sanguinis SK36 – Obelisk-S.s) indicates that Obelisks can be a component of bacterial cells; while we don’t know the “hosts” of other Obelisks, it is reasonable to assume that at least a fraction may be present in bacteria».

How can we not think of two Italian studies that discovered the presence of SARS-Cov-2 in the human intestinal metabiota and the “bacteriophage” behavior of SARS-Cov-2? Let’s reread the essential parts of them.

«Sars Cov 2 is also a bacteriophage virus. This means that it enters the bacteria and replicates its RNA from there too. We finally have scientific evidence, complete with photos of the virus colonizing the bacterium. This means that we are following procedures to integrate. To eradicate it, something more than classic viruses is needed. We don’t just need closures, we need to disinfect and prevent. And now there is the scientific rationale why antibiotics work. We will also need a vaccine against the toxins that we have found and our bacteria produce, very similar to the mechanism of diphtheria. Current vaccines will not be enough. Soon we will have many more variants: the Lombard, Venetian, Milan and Rome variants».

Dr. Carlo Brogna, director of the Craniomed company founded in 2018 in Montemiletto (AV) to study proteins, revealed these conclusions as we reported by Gospa News in an complex investigation of 21 April 2022.

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«Scientific evidence of the involvement of the human microbiota in the development of the COVID-19 disease has recently been reported. The presence of SARS-CoV-2 RNA was observed in human fecal samples and SARS-CoV-2 activity in the feces of COVID-19 patients. Starting from these observations, an experimental design was developed to cultivate the fecal microbiota of infected individuals in vitro, to monitor the presence of SARS-CoV-2 and to collect data on the relationship between fecal bacteria and viruses” wrote the researcher.

«Although based on a single observation, our results suggest that the SARS-CoV-2 genome, or parts of it, in addition to its known interactions with eukaryotic cells, is capable of replicating outside the human body, insinuating a possible “bacteriophage” mode of action» we read in relation to the other research of some of the Italian doctors already mentioned (C. Borgna, Cristoni, Piscopo) with the fundamental collaboration of Barbara Brogna, of the Radiology Department of the Hospital Moscati di Avellino, and other colleagues Domenico Rocco Bisaccia, Francesco Lauritano, Marino Giuliano, Luigi Montano and Marina Prisco (source Ricerca 4).

A close relationship has therefore been proven between the behavior of unknown Obelisks and the SARS-Cov-2 one, whose pathogenic agent of the toxic Spike protein is reproduced in the human body by mRNA vaccines to elicit the antibody reaction.

The anomalies in the RNA rod-like similar to those of Covid vaccines

The subsequent genomic analysis of the Obelisks carried out by Stanford University using a sophisticated technique revealed disturbing similarities with the ribosomal problems caused by the diabolical vaccine molecule: the infamous N1-methylpseudouridine.

«Viroids and Delta viruses are in part typified by their single stranded, circular genomes, both of which are molecular features that can be detected in strand specific RNA-seq. To search for such features in microbiome RNA sequencing (RNA-seq) datasets, we created a bioinformatic tool,VNom(see VNom, andSupplementary Figure 2), and applied it to microbiome RNA-seq datasets (see Initial Obelisk identification)» the American researchers write.

«One class of 15 related (<2 % sequence variation, Supplementary Table 1), 1164 nt RNAs stood out with their extended predicted secondary structure reminiscent of HDV and Pospiviroidae (Figure 1b, Supplementary Figures 1a-b and 2b). Owing to a strong predicted rod-like secondary structure, we term this group of RNAs Obelisk-alpha (Obelisk-ɑ, “Obelisk_000001” in Supplementary Table 1)».

«At 1164 nt in length, the rod-like secondary structure was striking because typical mRNA sequences are not predicted to readily fold in this manner (as evidenced by the efforts required to maximise the degree of “rod-ness” in mRNA vaccines22)».

Before continuing with the sensational and exceptional genomic findings, we report the University of Cambridge’s discovery of the anomalous phenomenon of “frame-shifting” related to Pfizer-Biontech’s Covid mRNA gene serum.

«The researchers identified that bases with a chemical modification called N1-methylpseudouridine – which are currently contained in mRNA therapies – are responsible for the ‘slips’ along the mRNA sequence» adds the Cambridge university website on the study by Mulroney et al. published December 6, 2023 in Nature after more than a month of review.

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The Canadian biochemist Jessica Rose pointed out with considerable emphasis this phenomenon:

«The modified mRNAs for use in the COVID-19 products were codon-optimized for maximal protein expression in humans. Codon optimization, or synonymous codon replacement, rests on the idea that one can induce mutations throughout a gene of interest (like spike) based on an organism’s (like humans) codon usage bias, to increase translational efficiency and protein expression without altering the sequence of the protein. But, it is well-known that codon-optimization can lead to protein conformation, folding and stability problems».

Let us therefore reread the sentence from the research by Zheludev et al. on the Obelisks:

«At 1164 nt in length, the rod-like secondary structure was striking because typical mRNA sequences are not predicted to readily fold in this manner (as evidenced by the efforts required to maximise the degree of “rod-ness” in mRNA vaccines22)».

Missing RNA Bases as in Perez’s study on mRNA Genetic Sera

«The Stanford search yielded nearly 30,000 predicted RNA circles, each consisting of about 1000 bases and likely representing a distinct obelisk. They were unlikely to be bona fide viruses, the team concluded, because RNA viruses typically have many more bases. But some of the obelisk sequences encoded proteins involved in RNA replication, making them more complex than standard viroids. Like viroids, however, obelisks don’t seem to encode proteins that make up a shell. Roux says further work is needed to see how distinct obelisks are from viroids and other viroidlike particles».

This is that the magazine SCIENCE reported in its article on the Stanford University study.

One can think of mRNA vaccines as instructions used to make spike proteins. In the case of COVID-19 vaccines, the mRNA vaccines contain a high percentage of pseudouridine, which is less common in the human body. The extra pseudouridine makes the process more prone to “frameshift errors.”

Recall that frameshift errors occur when the cell’s protein production machinery accidentally misses one or two bases in the mRNA sequence. Since mRNA bases are read in groups of threes, a frameshift breaks up the original sets of the sequence, affecting all sequences downstream of the error.

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In his research, Perez found that a one-base frameshift maintains the prion-like sequences, while a two-base frameshift eliminates them. She also found that frameshift sequences share similarities with bacterial brain-eating amoeba proteins and with human nucleases, proteins capable of breaking DNA bonds.

«Based on open reading frame (ORF) predictions, Obelisk-ɑ has the capacity to code for two proteins (202 and 53 amino acids [aa]). Both open reading frames (ORFs) lack evident nucleotide or protein sequence homology when querying a number of reference databases (NCBI nt, nr, or CDD 23, Pfam 24)» we read further in the study by Zheludev et al.which confirms the anomalous characteristic of generating unknown proteins as feared for the frame-shifting mechanisms of Covid mRNA genetic sera.

«Tertiary structure protein alignment yielded similar negative results (see Protein tertiary structure prediction).  As such, we chose new names, terming these two proteins Oblin-1 and Oblin-2, respectively. We specifically note that despite some similar characteristics between Obelisk-ɑ and HDV (apparently circular, predicted highly structured RNA genome, and ability to code for at least one 200 aa ORF, Supplementary Figure 1a), there is no evident sequence homology at the RNA or protein level or structural homology at the protein level between Obelisks and HDV». 

«In further contrast to HDV, whose large hepatitis Delta antigen (L-HDAg) occurs on one strand of the extended HDV predicted secondary structure (Supplementary Figure 1a), the Obelisk-ɑ Oblin-1 encoding region is largely self-complementary within the open reading frame, forming a 300 base pair hairpin making up half of the predicted Obelisk-ɑ RNA secondary structure».

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Are these considerations sufficient to reasonably suspect that the Obelisks were generated by the mRNA Covid vaccines?

We think so but it will be the experts we will soon consult who will have to answer…

While other scientists are excited about the Obelisk discovery… Other scientists are delighted by obelisks’ debut. “It’s insane,” says Mark Peifer, a cell and developmental biologist at the University of North Carolina at Chapel Hill. “The more we look, the more crazy things we see.” SCIENCE Journal reported.

However, it would be very insane if they were really a legacy of the mRNA genetic sera!

Fabio Giuseppe Carlo Carisio
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MAIN SOURCES

BIORXIV – FIRE ET AL. – Viroid-like colonists of human microbiomes

SCIENCE – ‘It’s insane’: New viruslike entities found in human gut microbes

GOSPA NEWS – COVID-19, VACCINES & BIG PHARMA DOSSIER

GOSPA NEWS – WUHAN-GATES DOSSIER

Billions of DNA Fragments of Toxic Spike Protein and SV40 gene in the mRNA Vaccines. New Study: “They may Cause Turbo-Cancer”

 

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