Needle-free Ultrasound Vaccine. From Oxford a Shocking Invention Helpful for mDNA Delivery

Does the sight of a syringe make your heart pound or cause you to break out in a cold sweat? If so, you’re not alone ——a quarter of adults and two-thirds of children are afraid of needles, which poses a problem for doctors trying to administer vaccines that are necessary to maintain public health.

But as far as phobias go, a fear of needles isn’t all that unreasonable. Although vaccines are more effective than ever, the most prominent method of administering them remains somewhat primitive. Getting jabbed hurts, can expose you to blood-borne pathogens, and is a source of dangerous medical waste.

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With all those risk factors in mind, it’s no wonder that scientists are eager to develop methods of vaccine delivery that don’t rely on needles. Some promising alternatives include nasal sprays, electric shocks, and even air-powered “guns” that shoot vaccines through the skin.

Now, a team of researchers at the University of Oxford is harnessing the power of ultrasound to deliver vaccines in a manner that is safe, painless, effective, and—most importantly—completely needle-free.

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The new technique, which was presented earlier this month at an event co-hosted by the Acoustical Society of America and the Australian Acoustic Society, relies on a phenomenon known as “cavitation” in which sound waves traveling through liquid cause many small bubbles to form and then immediately implode.

The researchers are attempting to use the energy produced by those popping bubbles to push past the outer layers of dead skin cells and thrust vaccine molecules straight through the membranes of the living cells below.

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When the approach was tested in mice, it delivered about 700 times fewer drug particles than a conventional intramuscular injection. But because ultrasonic drug delivery targets the skin, which is richer in immune cells than muscle, it also caused the animals to produce more antibodies.

So, in addition to causing fewer side effects, ultrasound-based vaccine delivery may be more efficient and effective—provoking stronger immune responses with less medicine, and ultimately providing better protection against disease.

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The cavitation approach could prove especially helpful for DNA vaccines, which are safer and more potent than other types of vaccines but are difficult to deliver because they have to gain access to cell nuclei in order to work correctly.

Focused sound waves could break open the protective membrane that surrounds a cell’s nucleus, allowing vaccine molecules to move in and get to work.

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Of course, this needle-free technique carries its own risks. Excessive exposure to cavitation can cause damage to neighboring cells, but the team says this damage can be avoided if the sound waves are precisely targeted. Also, as lead researcher Darcy Dunn-Lawless points out, no method of vaccine delivery will ever be entirely danger-free.

“The main potential side effect is universal to all physical techniques in medicine,”  he explains in a press release. “If you apply too much energy to the body, you can damage tissue.”

Unlike needle-based vaccine delivery, ultrasound also carries no risk of cross-infection and doesn’t produce hazardous waste. And perhaps most importantly, while a huge number of people are terrified of needles, there really isn’t anything scary about sound waves you can’t even hear.

Originally published on Future News – SCIENCE Journal Newsletter 

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